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Synfacts 2009(4): 0432-0432  
DOI: 10.1055/s-0028-1087829
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Unsymmetrical Nickel-Catalyzed Oxidative Coupling of Terminal Alkynes

Contributor(s): Paul Knochel, Tobias Thaler
W. Yin, C. He, M. Chen, H. Zhang, A. Lei*
Wuhan University, P. R. of China
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Publikationsverlauf

Publikationsdatum:
23. März 2009 (online)

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Significance

A Ni/Cu-cocatalyzed oxidative coupling between two different terminal alkynes was discovered. NiCl2 and CuI are hereby supposed to catalyze the reaction in a synergistic way. Efficient heterocoupling was achieved by employing an excess of one terminal alkyne (five equivalents).