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Pd/HP20-Catalyzed Hydrogenation and Suzuki-Miyaura Coupling
Y. Monguchi, Y. Fujita, K. Endo, S. Takao, M. Yoshimura, Y. Takagi, T. Maegawa, H. Sajiki*
Gifu Pharmaceutical University and N.E. Chemcat Corporation, Shizuoka, Japan
23 March 2009 (online)
Palladium on DIAION® HP20 (Pd/HP20) was prepared by mixing Pd(OAc)2 and DIAION® HP20 in MeOH at room temperature under argon atmosphere for four days (eq. 1). Pd/HP20 catalyzes the hydrogenolysis of N-benzyl-oxycarbonyl and benzyl groups, the hydro-genation of alkyne and nitro groups, etc. (eq. 2). Pd/HP20 was also applied to the Suzuki-Miyaura coupling of aryl bromides and arylboronic acids to give the corresponding biaryl compounds (eq. 3).