Synfacts 2009(4): 0403-0403  
DOI: 10.1055/s-0028-1087872
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Planar-Chiral Catalyst for Friedel-Crafts Alkylation of Indoles

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
H. Huang, R. Peters*
Universität Stuttgart, Germany and ETH Zürich, Switzerland
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23. März 2009 (online)


There have been an increasing number of reports in the past few years utilizing platinum and gold catalysts. These catalysts have been shown to activate unsaturated moieties such as alkynes, alkenes, and allenes. Additionally, their low oxophilicity and tolerance to water and air is a benefit to use them as catalysts. Platinum olefin complexes are known to be susceptible to nucleophilic attack. The authors exploit this fact in this report on an intramolecular enantioselective Friedel-Crafts alkylation of indoles.