Synfacts 2009(4): 0414-0414  
DOI: 10.1055/s-0028-1087879
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

BINOL Derivative Catalyzed Enantioselective Diethylzinc Alkylation

Contributor(s): Hisashi Yamamoto, Zhi Li
S. Gou, Z. M. A. Judeh*
Nanyang Technological University, Singapore
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23. März 2009 (online)


This article described a new type of BINOL derivative ligand that can be used catalytically in Ti(IV)-mediated diethylzinc addition reactions. The ligand features spatial expansion of BINOL chirality and coordination ability by linking a substituted phenol to each BINOL hydroxyl group. Effect of this ligand was carefully examined.