Synfacts 2009(4): 0417-0417  
DOI: 10.1055/s-0028-1087905
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Direct Cross-Coupling of Alkenes and Acrylates

Contributor(s): Mark Lautens, Praew Thansandote
Y.-H. Xu, J. Lu, T.-P. Loh*
Nanyang Technological University, Singapore
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23. März 2009 (online)


A palladium-catalyzed direct cross-coupling between alkenes and acrylates is reported. The scope is broad and the E/Z selectivities are good, although the yields are moderate to low. Overall, this is an efficient method for synthesizing dienoates using simple olefins and mild reaction conditions.