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Synfacts 2009(4): 0356-0356  
DOI: 10.1055/s-0028-1088093
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of Tamiflu®

Contributor(s): Philip Kocienski, Stewart Eccles
M. Matveenko, A. C. Willis, M. G. Banwell*
The Australian National University, Canberra, Australia
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Publikationsdatum:
23. März 2009 (online)

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Significance

Tamiflu® is used as a treatment for influenza as well as to prevent infections. The active drug is the free acid which inhibits the enzymes necessary for viral replication, neurami­nidases A and B. The synthesis of Banwell and co-workers starts with the commercial diol A, which is derived from microbial dihydroxylation of bromobenzene.