Download PDF
Horm Metab Res 1976; 8(3): 226-231
DOI: 10.1055/s-0028-1093646
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Pituitary and Extrapituitary Effects of Somatostatin in Normal Man

G.  Copinschi1 , V.  Leclercq-Meyer1 , E.  Virasoro1 , M.  L'Hermite2 , L.  Vanhaelst1 , J.  Golstein3 , R.  Leclercq4 , F.  Féry1 , C.  Robyn2
  • 1Laboratories of Experimental Medicine, Universities of Brussels, Belgium
  • 2Human Reproduction Research Unit, Universities of Brussels, Belgium
  • 3Institute of Interdisciplinary Research (LMN), Faculty of Medicine, Universities of Brussels, Belgium
  • 4Laboratory, IMC Anderlecht and Department of Radioimmunology, Laboratory of Clinical Pathology, Institute Edith Cavell - Marie Depage, Brussels, Belgium
Further Information

Publication History

Publication Date:
23 December 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

The effects of synthetic linear somatostatin on basal circulating levels of several pituitary and pancreatic hormones, and of glucose and free fatty acids (FFA) were studied in 6 normal men after an overnight fast. A priming intravenous infusion of 250 µg of somatostatin in 18 sec was followed by a constant infusion of 500 µg over a period of 60 min. A decrease in plasma values of GH, prolactin, TSH, insulin and glucagon and in blood glucose was observed during somatostatin infusion, while FFA levels increased progressively. Plasma IRI and blood glucose increased rapidly when the somatostatin infusion was stopped, while FFA decreased progressively; GH, prolactin, TSH and glucagon remained low as compared to basal levels for one hour after the end of the infusion, i.e. until the end of the experiment. A slight but significant increase of LH and ACTH was observed after the end of the infusion.

Key words

Somatostatin - Plasma Cortisol - LH - FSH - PRL - ACTH - GH - TSH - Insulin and Glucagon - Blood Glucose

      >