Glibenclamide (G) had a diuretic effect during ad libitum fluid intake as well as
during maximal sustained water diuresis in patients with pituitary diabetes insipidus.
The diuretic effect could be demonstrated also in healthy subjects during maximal
sustained water diuresis. No antagonism was found between small doses of lysine-vasopressin
and G. Diuretic action of G seems not to be mediated through inhibition of the release
or/and renal effect of antidiuretic hormone (ADH). An effect on the water reabsorbing
mechanism not depending on ADH was supposed. Diuretic effect of G has important clinical
implications.
Glibenclamide - Diabetes Insipidus - Diuretic Effect
