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Horm Metab Res 1974; 6(4): 289-292
DOI: 10.1055/s-0028-1093850
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© Georg Thieme Verlag KG Stuttgart · New York

Investigation of the Diuretic Effect of Glibenclamide in Healthy Subjects and in Patients with Pituitary and Nephrogenic Diabetes Insipidus

J. P. Radó , L.  Borbély , L.  Szende , J.  Fischer , J.  Takó
  • Isotopic Department and Metabolic Unit, Janos Hospital, Budapest, Hungary
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Publication History

Publication Date:
08 January 2009 (online)

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Abstract

Glibenclamide (G) had a diuretic effect during ad libitum fluid intake as well as during maximal sustained water diuresis in patients with pituitary diabetes insipidus. The diuretic effect could be demonstrated also in healthy subjects during maximal sustained water diuresis. No antagonism was found between small doses of lysine-vasopressin and G. Diuretic action of G seems not to be mediated through inhibition of the release or/and renal effect of antidiuretic hormone (ADH). An effect on the water reabsorbing mechanism not depending on ADH was supposed. Diuretic effect of G has important clinical implications.

Key words

Glibenclamide - Diabetes Insipidus - Diuretic Effect

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