Blood flow, plasma and interstitial insulin levels and tissue glucose uptake were
measured in the exercising hind limb of the dog. Blood flow and glucose utilization
were markedly enhanced. Plasma non-suppressible insulin-like activity (NSILA) and
immuno-reactive insulin (IRI), as well as lymph protein and IRI levels did not change;
only lymph NSILA displayed a manifold increase. It is suggested that "de novo" production
of NSILA in the working area might be responsible for both the rise of lymph NSILA
and the increased tissular glucose utilization.
Glucose Utilization - Exercise - Immunoreactive Insulin - Non-Suppressible Insulin-Like
Activity - Blood Flow - Lymph
