Relationship between Antidepressant Effect and Plasma Level of Nortriptyline. Clinical Studies.*

P. Kragh-Sørensen; Chr. Eggert Hansen; P. Chr Baastrup; E. F. Hvidberg

doi:10.1055/s-0028-1094474

Pharmacopsychiatry 1976; 9(1): 27-32
DOI: 10.1055/s-0028-1094474

Originalarbeiten

Relationship between Antidepressant Effect and Plasma Level of Nortriptyline. Clinical Studies.^*

Klinische Studien zum Zusammenhang zwischen antidepressiver Wirkung und Plasma-NortriptylinP. Kragh-Sørensen, Chr. Eggert Hansen, P.Chr. Baastrup, E.F. Hvidberg

The State Mental Hospital, Glostrup, The Department of Clinical Chemistry, Glostrup Hospital, and Clinical Research Unit, Rigshospitalet, University of Copenhagen, Denmark.

Supported by grants from the Danish State Medical Research Council.

Abstract

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Summary

Strong evidence has been found for the assumption that NT inhibits its own antidepressive effect at high, but non toxic plasma levels in patients suffering from endogenous depression. Based on three investigations we will recommend an optimal therapeutic plasma range for NT between 50 and 150 ng NT/ml.

^* Anna-Monika Lecture, München 1975

Zusammenfassung

Viele Befunde sprechen dafür, daß Nortryptilin in endogen-depressiven Patienten bei hohen, nicht toxischen Plasmaspiegeln seinen eigenen antidepressiven Effekt hemmt. Auf der Grundlage von drei Untersuchungen empfehlen wir einen optimalen Nortriptylin-Plasmaspiegel zwischen 50 und 150 ng/mL

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