Urinary cyclic AMP was studied in 22 female and in 6 male hyperthyroid normocalcemic
patients and in 3 hyperthyroid hypercalcemic men. Cyclic AMP/creatinine ratios were
elevated both in female (4.12±0.26 µmoles/gm creatinine) and male (3.92±0.41 µmoles/gm
creatinine) hyperthyroid normocalcemic patients as compared with normal female and
male controls (2.85±0.20 and 2.54±0.14 µmoles/gm crcatinine, respectively). However,
there was no difference in the 24-hour urinary cyclic AMP excretion of both hyperthyroid
and normal subjects. The hyperthyroid hypercalcemic men excreted less (2.47±0.19 µmoles/24
hr) cyclic AMP/24 hr than the normal male controls. In the thirteen female patients,
studied when euthyroid, the cyclic AMP/creatinine ratio was normalised.
Urinary Cyclic AMP - Urinary Creatinine - Normocalcemic and Hypercalcemic Hyperthyroidism
