Abstract
The hormonal properties of coronaridine hydrochloride were investigated. A single
oral administration of the compound (30 mg/kg) prevented pregnancy in rats when given
on days 1, 2, 3 or 4 post–coitum; the effect on days 5, 6, 7 or 8 of pregnancy was,
however, partial. The substance showed estrogenic activity but was devoid of antiestrogenic,
androgenic, antiandrogenic, progestational, antiprogestational and uterine stimulant
activities; however, there was a partial inhibition of oxytocin–induced uterine response.
Coronaridine appears to exert its antifertility action due to its frank estrogenicity.
Key Word Index
Coronaridine hydrochloride - Antifertility Action - Oestrogenic Activity
