The Effects of Saikosaponins on Biological Membranes

Hiroko Abe; Shizuo Odashima; Shigeru Arichi

doi:10.1055/s-0028-1097452

Planta Med 1978; 34(7): 287-290
DOI: 10.1055/s-0028-1097452

Research Articles

The Effects of Saikosaponins on Biological Membranes

2. Changes in Electron Spin Resonance Spectra from Spin–Labelled Erythrocyte and Erythrocyte Ghost MembranesHiroko Abe¹ , Shizuo Odashima² , Shigeru Arichi¹

¹The Research Institute of Oriental Medicine, Kinki University School of Medicine, Sayama–cho, Minami–kawachi–gun, Osaka, Japan.
²Department of Pathology, Kanazawa Medical University, Uchinadamachi, Ishikawa, Japan,

Abstract

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Abstract

The effects of saikosaponins a, b ₁, b₂, c and d, isolated from the root of Bupleurum falcatum L., on membrane fluidity using spin–labelled erythroeytes were examined. Saikosaponins a and b₂ in which the C–16 OH of epoxyoleanene skeleton is in β position caused the remarkable decrease of membrane fluidity but saikosaponin d and b₂ in which the 16 OH is in a position showed weaker actions on membrane fluidity.

Key Word Index

Bupleurum falcatum L - Saikosaponin - Spin–label - Membrane fluidity

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