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DOI: 10.1055/s-0028-1098101
© Georg Thieme Verlag, Stuttgart
Pylorokardiale Expansion der Gastritis? (Bioptische und funktionelle Untersuchungen)[*]
Publication History
Publication Date:
08 December 2008 (online)
Summary
In 200 subjects 1200 particles from the antral, fundic and cardial region of the stomach were biopsied under endoscopic control and the degree of inflammation determined. In 117 subjects with normal fundic mucosa and with either normal mucosa of the antrum or with varying degrees of antrum gastritis, gastric secretion analyses were carried out. The severity of gastritis decreased from the antrum to the cardia. When gastritis of the cardial region of the stomach is found, the probability of the whole gastric mucosa being inflamed is high. In subjects with an isolated chronic atrophic gastritis of the antrum, basal as well as stimulated gastric secretion was significantly lower than in those with normal gastric mucosa. Hypogastrinism followed by trophic-hormonal atrophy of the parietal cell may be the cause of this phenomenon. Further investigation is necessary to clarify if this atrophy promotes a pyloric-cardial expansion of gastritis.
Key-Words
Gastritis - gastroscopic biopsy - acid secretion