Int J Sports Med 2009; 30(2): 75-79
DOI: 10.1055/s-0028-1104572
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Cardiac Injury Markers in Non-elite Marathon Runners

D. S. Jassal 1 , D. Moffat 2 , J. Krahn 3 , R. Ahmadie 1 , T. Fang 1 , G. Eschun 4 , S. Sharma 4
  • 1Department of Cardiology, Cardiac Sciences, University of Manitoba, Winnipeg, Canada
  • 2Internal Medicine, University of Manitoba, Winnipeg, Canada
  • 3Laboratory Medicine, University of Manitoba, Winnipeg, Canada
  • 4Pulmonary Medicine and Critical Care, University of Manitoba, Winnipeg, Canada
Further Information

Publication History

accepted after revision July 14, 2008

Publication Date:
28 January 2009 (online)


An elevation of cardiac injury markers including creatinine kinase (CK), myoglobin (Myo) and cardiac troponin T (cTnT) has been observed in elite athletes following strenuous exercise. The mechanism and significance of this observation however have not been fully elucidated. The goals of this study were: 1) to determine whether these changes in biomarkers also occur in a large, heterogeneous group of non-elite athletes; and 2) to identify possible clinical or biochemical associations. We recruited 129 non-elite runners in 2006, 61 individuals who were taking part in the half (13.1 miles) marathon and 68 individuals participating in the full (26.2 miles) marathon. Demographic data and blood samples were collected for analysis of CK, Myo, cTnT, and Creatinine (Cr) levels within two hours of race start, at race completion, and 1-h post-race for both patient cohorts. In the 61 individuals (40 males, 40±12 yrs) completing the half marathon in a mean time of 150±20 min, 90.3%, 65.2%, and 30.6% of the subjects exhibited significant elevations in Myo, CK, and cTnT, respectively immediately post race and 100%, 74.9% and 45.9% in the same biomarkers one hour-post race. In the 68 individuals (44 males, 42±14 yrs) completing the full marathon in a mean time of 310±30 min, 95.3%, 70.2% and 35.7% exhibited significant elevations in Myo, CK and cTnT respectively immediately post race and 100%, 78.5% and 52.8% in the same biomarkers one hour-post race. The elevation in cTnT levels post-race were modestly associated with the time required to complete the race for the entire cohort of marathon runners. The serum levels of Cr, CK, and Myo post-race did not correlate however with age, sex, BMI, level of training, or prior marathon experience. Elevations of cardiac injury markers in non-elite athletes are extremely common following the completion of endurance events and correlate to the increased endurance time. Whether the increase in the levels of these enzymes represents true myocardial injury or a result of the release of cTnT from the myocytes requires further investigation.


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Sat Sharma MD, FRCPC, FCCP 

Department of Internal Medicine Head

Section of Respirology University of Manitoba BG 034

St. Boniface General Hospital

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Winnipeg Manitoba Canada

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