Planta Medica, Table of Contents Planta Med 2009; 75(10): 1168-1170DOI: 10.1055/s-0029-1185449 Natural Product ChemistryLetter© Georg Thieme Verlag KG Stuttgart · New York15-Lipoxygenase Inhibitory Effects of Prenylated Flavonoids from Erythrina senegalensis Adiaratou Togola1 , 2 , Berte Hedding1 , Anette Theis1 , Helle Wangensteen1 , Frode Rise3 , Berit Smestad Paulsen1 , Drissa Diallo2 , Karl Egil Malterud1 1Section of Pharmacognosy, Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, Oslo, Norway 2Département de Médecine Traditionnelle, Institut National de Recherche en Santé Publique, Bamako, Mali 3Department of Chemistry, University of Oslo, Oslo, Norway Recommend Article Abstract Buy Article(opens in new window) Abstract One new pterocarpan (named erybraedin F) along with seven known prenylated flavonoids were isolated from the stem and root bark of the medicinal plant Erythrina senegalensis. The structures were elucidated by 1D and 2D NMR and MS. The pterocarpans were found to be strong inhibitors of 15-lipoxygenase. Key words Erythrina senegalensis (Fabaceae) - pterocarpans - flavonoid - DPPH - 15‐lipoxygenase Full Text References References 1 Burkill H M. The useful plants of West tropical Africa. Kew; Royal Botanic Gardens 1995 2 Togola A, Diallo D, Dembele S, Barsett H, Paulsen B S. Ethnopharmacological survey of different uses of seven medicinal plants from Mali, (West Africa) in the regions Doila, Kolokani and Siby. J Ethnobiol Ethnomed. 2005; 1 7-15 3 Saidu K, Onah J, Orisadipe A, Olusola A, Wambebe C, Gamaniel K. Antiplasmodial, analgesic, and anti-inflammatory activities of the aqueous extract of the stem bark of Erythrina senegalensis. J Ethnopharmacol. 2000; 71 275-280 4 Oh W K, Lee H S, Ahn S C, Ahn J S, Mbafor J T, Wandji J, Fomum Z T, Chang H K, Kim Y H. Prenylated isoflavonoids from Erythrina senegalensis. Phytochemistry. 1999; 51 1147-1150 5 Wandji J, Awanchiri S S, Fomum Z T, Tillequin F, Libot F. Isoflavones and alkaloids from the stem bark and seeds of Erythrina senegalensis. Phytochemistry. 1995; 39 677-681 6 Wandji J, Awanchiri S S, Fomum Z T, Tillequin F, Michel-Daniwicz S. Prenylated isoflavonoids from Erythrina senegalensis. Phytochemistry. 1995; 38 1309-1313 7 Wandji J, Fomum Z T, Tillequin F, Baudouin G, Koch M. Epoxyisoflavones from Erythrina senegalensis. Phytochemistry. 1994; 35 1573-1577 8 Wandji J, Fomum Z T, Tillequin F, Skaltsounis A L, Koch M. Erysenegalenseins H and I: two new isoflavones from Erythrina senegalensis. Planta Med. 1994; 60 178-180 9 Tanaka H, Hirata M, Etoh H, Sako M, Sato M, Murata J, Murata H, Darnaedi D, Fukai T. Four new isoflavonoids and a new 2-arylbenzofuran from the roots of Erythrina variegata. Heterocycles. 2003; 60 2767-2773 10 Kitagawa I, Chen W Z, Hori K, Harada E, Yasuda N, Yoshikawa M, Ren J. Chemical studies of Chinese licorice-roots. I. Elucidation of five new flavonoid constituents from the roots of Glycyrrhiza glabra L. collected in Xinjiang. Chem Pharm Bull. 1994; 42 1056-1062 11 Kiss L, Kurtan T, Antus S, Benyei A. Chiroptical properties and synthesis of enantiopure cis and trans pterocarpan skeleton. Chirality. 2003; 15 558-563 12 Mitscher L A, Okwute S K, Gollapudi S R, Drake S, Avona E. Antimicrobial pterocarpans of Nigerian Erythrina mildbraedii. Phytochemistry. 1988; 27 3449-3452 13 Nkengfack A E, Vardamides J C, Fomum Z T, Meyer M. Prenylated isoflavanone from Erythrina eriotricha. Phytochemistry. 1995; 40 1803-1808 14 Mitscher L A, Okwute S K, Gollapudi S R, Keshavarzshokri A. Antimicrobial agents from higher plants. The isolation and structural characterization of 2 additional pterocarpan antimicrobial agents from Nigerian Erythrina mildbraedii. Heterocycles. 1988; 27 2517-2522 15 Bailey J A, Burden R S, Mynett A, Brown C. Metabolism of phaseollin by Septoria nodorum and other non-pathogens of Phaseolus vulgaris. Phytochemistry. 1977; 16 1541-1544 16 Bowen I H, Patel Y N. Acridone alkaloids and other constituents of the leaves of Atalantia ceylanica. Planta Med. 1987; 53 73-75 17 Saraswathy A, Balakrishna R, Rao R B, Allirani T, Patra A, Pichai R. Carpachromene from Atalantia monophylla. Fitoterapia. 1998; 69 463-464 18 Wangensteen H, Samuelsen A B, Malterud K E. Antioxidant activity in extracts from coriander. Food Chem. 2004; 88 293-297 19 Wangensteen H, Alamgir M, Rajia S, Meza T J, Samuelsen A B, Malterud K E. Cytotoxicity and brine shrimp lethality of rotenoids and extracts from Sarcolobus globosus. Nat Prod Commun. 2007; 2 841-844 Karl Egil Malterud Department of Pharmaceutical ChemistryDivision of PharmacognosySchool of PharmacyUniversity of Oslo P. O. Box 1068 0316 Oslo Norway Phone: + 47 22 85 65 63 Email: k.e.malterud@farmasi.uio.no
