Chemical Constituents of Dracocephalum forrestii

Abstract

A systematic phytochemical examination of the whole plant Dracocephalum forrestii led to the isolation of 4 new and 65 known chemical constituents. By detailed 1D and 2D NMR spectroscopic analyses, the new compounds were identified as 4-hydroxy-3-methoxyphenylethanol 8-O-[(6-O-syringoyl)-β-D-glucopyranoside] (1), 3,4,5-trimethoxyphenylethanol β-D-glucopyranoside (2), 4-O-[β-D-glucopyranosyl-(1 → 3)-α-L-rhamnopyranosyl]phenylethylcinnamamide (3), and 9″-O-n-butyl lithospermate (4). The new isolates were evaluated for inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages. Compound 2 revealed a moderate effect without any cytotoxicity under the assayed concentrations.

Key words

Dracocephalum forrestii - Lamiaceae - phenylethanoids - lignans - RAW 264.7 macrophages - NO

References

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