Genexpressionsstudien beim Lungenkarzinom

Zusammenfassung

Die Mikroarray-Technologie erfasst simultan die globale Genexpression in Zellen und Geweben. Sie liefert wichtige Erkenntnisse über die transkriptionellen Veränderungen der Gene in Tumoren. Die resultierenden Genexpressionsprofile können zur Vorhersage der Diagnose, Prognose oder des Therapieerfolges der Erkrankung, sowie für die Suche nach neuen therapeutischen Zielstrukturen genutzt werden.

Summary

The microarray technology allows simultaneous analysis of the global gene expression in cells and tissues. In tumor diseases, important transcriptional changes of genes have been unravelled by this method. The resulted gene expression profiles can be used for the prediction of diagnosis, prognosis or therapeutic outcome, as well as for the identification of novel drug targets. Our review depicts state-of-the-art, limitations, translational applications and future directions concerning microarray analyses in lung cancer.

Schlüsselwörter

Mikroarray - Genexpression - Lungenkrebs

Keywords

microarray - gene expression - lung cancer

Literatur

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