Triiodothyronine in the Treatment of Hirsute Girls1)

M. Szamatowicz; M. Kulikowski

doi:10.1055/s-0029-1210250

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 1983; 82(4): 15-20
DOI: 10.1055/s-0029-1210250

Original

Triiodothyronine in the Treatment of Hirsute Girls¹)

M. Szamatowicz, M. Kulikowski

Department of Gynecological Endocrinology (Head: Prof. dr hab. M. Szamatowicz) Institute of Obstetrics and Gynecology of Medical Academy (Head: Prof. dr hab. S. Soszka) Białystok/Poland

1) This paper was supported by Ministry of Health and Social Care (Research program 10-MZ-VII-10).

Abstract

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Summary

Twenty six girls with hirsutism and menstrual disturbances were investigated.

The girls participated in 9-day dynamic tests with dexamethasone and human ehorionic gonadotrophin and using serum testosterone(T), dihydrotestosterone(DHT) and sex hormone binding globulin (SHBG) capacity estimations three groups of hirsutism (adrenal, ovarian, and mixed) were diagnosed.

In the treatment of hirsute girls the triiodothyronine (T₃) alone, T₃ with dexamethasone and T₃ with contraceptive pills (Gestranol) were employed.

Before and during treatment serum concentrations of T, DHT and SHBG were determined. While and effect of T₃ on T and DHT serum levels could not be established statistically, SHBG capacity increased signficantly in comparison to their initial values. This increase was more evident after an addition of dexamethasone (adrenal type of hirsutism)and Gestranol (ovarian type of hirsutism).

The employed treatment led to the regulation of menstrual bleedings and in most cases caused an inhibition of an excessive growth of body hair.

The authors suggest that the administration of thyroid gland preparations should be considered in the treatment of hirsutism in young individuals.

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