The effect of secretin on insulin release has been studied in normal subjects after
prestimulation with arginine. In order to make a comparison a pulse of glucose with
arginine prestimulation was given.
A pulse of 1 U/kg b.w. of secretin provokes a secretion of insulin that is weak and
brief compared to that provoked by glucose; thus secretin fails to potentiate arginine-induced
insulin secretion.
Such a result does not support the hypothesis of secretin as the central hormone in
the enteroinsular axis.
Secretin - insulin release - arginine - glucose
