Further Report on the Endocrinological Profile of Two Synthetic Estrogens with Antifertility Properties, STS 456 and STS 593

M. Koch; T. I. Ivanenko; A. J. Kurischko; E. V. Pokrovskaya; V. P. Fedotov; H. Freund; M. Oettel

doi:10.1055/s-0029-1210495

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 1985; 86(6): 257-265
DOI: 10.1055/s-0029-1210495

Original

Further Report on the Endocrinological Profile of Two Synthetic Estrogens with Antifertility Properties, STS 456 and STS 593

M. Koch, T. I. Ivanenko¹ , A. J. Kurischko, E. V. Pokrovskaya¹ , V. P. Fedotov¹ , H. Freund, M. Oettel

Department of Experimental Endocrinology, Division of Steroid Hormone Research (Head: Prof. Dr. K. Schubert), Central Institute of Microbiology and Experimental Therapy (Director: Prof. Dr. F. Bergter), Academy of Sciences of the GDR, Jena/GDR
¹Institute of Experimental Endocrinology and Chemistry of Hormones, Academy of Medical Sciences of the USSR, Moscow/USSR

Abstract

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Summary

Two synthetic estrogens, STS 456 and STS 593, with noteworthy post-coital antifertility properties in the rat were studied for their estrogenic, antiestrogenic, progestagenic, antiprogestagenic, antigonadotrophic, androgenic and antiandrogenic effects in laboratory animals. Beside their weak estrogenic activity which corresponds to their slight affinity to the uterine estrogen receptor in the rat, both steroids show remarkable antiestrogenic effects. No progestagenic, androgenic and antiandrogenic effects were found but STS 593 showed some antiprogestagenic activity. The antigonadotrophic efficacy of STS 456 was relatively high while STS 593 was scarcely active. The results are discussed with respect to possible application of these drugs for interceptive purposes.

Key Words

Synthetic estrogens - post-coital antifertility - uterine receptor

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