The Modulating Effect of Estrogens on Luteinizing Hormone Release in complete Androgen Insensitivity Syndrome before and after Gonadectomy and Cyclic Steroid Application

G. Göretzlehner; W. Wodrig; M. Sas; J. Morvay; Bärbel Scholz; A. Weber; W. Schmidt

doi:10.1055/s-0029-1210678

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 1987; 90(4): 99-106
DOI: 10.1055/s-0029-1210678

Original

The Modulating Effect of Estrogens on Luteinizing Hormone Release in complete Androgen Insensitivity Syndrome before and after Gonadectomy and Cyclic Steroid Application

G. Göretzlehner, W. Wodrig, M. Sas² , J. Morvay² , Bärbel Scholz, A. Weber¹ , W. Schmidt¹

¹Department of Obstetrics and Gynaecology and Department of Radiology, Szeged/Hungary
²Ernst-Moritz-Arndt-University, Greifswald/GDR, and Medical University, Szeged/Hungary

Abstract

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Summary

The response of LH release to exogenous estrogens was studied in three patients with androgen insensitivity syndrome (AIS) before and after gonadectomy and a prolonged treatment with a sequential pill.

Estrogen provocation tests were performed in which 0.05 mg/kg body weight estradiol benzoate was administered intramuscularly and serum FSH and LH levels were assessed every 12 hours for 96 hours after gonadectomy, three months after a prolonged treatment with a sequential pill (16 cycles: 9 days mestranol 100 μg, 12 days mestranol 80 μg and chlormadinone acetate 2 mg) and in one patient before gonadectomy.

The control group consisted of 10 normal females during the follicular phase. A positive feedback effect was induced in normal females and in AIS patients after prolonged treatment with a sequential pill.

Key words

Androgen Insensitivity Syndrome - Gonadectomy - LH release - Exogenous estrogens - Positive feed back

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