Evidence for Pulsatile Secretion of Human Atrial Natriuretic Peptide in Healthy Subjects

T. Haak; E. Jungmann; K. Schöffling; K. H. Usadel

doi:10.1055/s-0029-1211147

Experimental and Clinical Endocrinology & Diabetes, Inhaltsverzeichnis

Exp Clin Endocrinol Diabetes 1992; 99(2): 108-109
DOI: 10.1055/s-0029-1211147

Original

Evidence for Pulsatile Secretion of Human Atrial Natriuretic Peptide in Healthy Subjects

T. Haak, E. Jungmann, K. Schöffling, K. H. Usadel

Department of Endocrinology (Head: Prof. Dr. med. K. H. Usadel), Center of Internal Medicine, Johann Wolfgang Goethe-University, Frankfurt am Main/Germany

Abstract

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Summary

The secretion pattern of human atrial natriuretic peptide (hANP) was investigated in 8 healthy male volunteers. Blood was drawn in 2 minute intervals for 90 minutes and in a second study in 4 minute intervals for 180 minutes. Base-line hANP plasma levels varied in a pulsatile secretion pattern of regular pulses every 9 ± 1 minutes. Additionally long-term oscillations of 34 ± 4 minutes were found.

These data suggest that under basal conditions hANP varies in a pulsatile fashion.

Key words

Human atrial natriuretic peptide (hANP) - Pulsatile secretion pattern

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