Exp Clin Endocrinol Diabetes 1996; 104(6): 447-453
DOI: 10.1055/s-0029-1211483

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The effects of a special Agnus castus extract (BP1095E1) on prolactin secretion in healthy male subjects

P.-G. Merz, C. Gorkow** , A. Schrödter, S. Rietbrock, C. Sieder** , D. Loew, J. S. E. Dericks-Tan* , H. D. Taubert*
  • Department for Clinical Pharmacology, Frankfurt University Clinic, Neumarkt, Germany
  • * Centre for Gynaecology and Obstetrics, Frankfurt University Clinic, Neumarkt, Germany
  • ** Bionorica GmbH, Neumarkt, Germany
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Publication History

Publication Date:
15 July 2009 (online)


The effects of three doses of a special Agnus castus extract (BP1095E1) – extracts from 120 mg, 240 mg and 480 mg of drug per day – were examined within the framework of a placebo-controlled clinical study of tolerance and prolactin secretion in 20 healthy male subjects during a period of 14 days. There was good tolerance during the study as regards the following: adverse effects, the effects on blood pressure and heart rate, blood count, Quick's test, clinical chemistry as well as testosterone, FSH and LH values. During each study phase the 24-hour prolactin secretion profile was measured from the penultimate to the final day, and the amount of prolactin release was monitored an hour after TRH stimulation on the last day. A significant increase in the 24-hour profile was registered with the lowest dose in comparison to placebo, the opposite being the case with the higher doses, i.e. a slight reduction. In contrast to the administration of placebo, the 1-hour AUC after TRH stimulation resulted in a significant increase with the lowest dose and a significant reduction with the highest dose. The results suggest effects of the special Agnus castus extract which are dependent on the dose administered and the initial level of prolactin concentration.