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Semin Liver Dis 2009; 29(2): 222-232
DOI: 10.1055/s-0029-1214377
© Thieme Medical Publishers

Role of Alcohol in Liver Carcinogenesis

Iain H. McKillop1 , Laura W. Schrum2
  • 1Department of General Surgery, Carolinas Medical Center, Charlotte, North Carolina
  • 2Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina
Further Information

Publication History

Publication Date:
22 April 2009 (online)

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ABSTRACT

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world and contributes significantly to cancer-related morbidity and mortality. Chronic alcohol consumption has long been associated with progressive liver disease toward the development of hepatic cirrhosis and the subsequent increased risk for developing HCC. In assessing the role of alcohol during hepatic disease, and as a carcinogen, many of the deleterious effects of alcohol can be attributed to alcohol metabolism in hepatocytes. In addition to the direct effects of alcohol/alcohol metabolism on hepatocyte transformation, increasing evidence indicates that other intrahepatic and systemic effects of alcohol are likely to play an equally significant role in the process of hepatic tumorigenesis.

KEYWORDS

Alcohol - acetaldehyde - hepatocellular carcinoma - carcinogenesis - metabolism

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Iain H McKillopPh.D. 

Department of General Surgery, Carolinas Medical Center

1000 Blythe Boulevard, Charlotte, NC 28203

Email: iain.mckillop@carolinashealthcare.org

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