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Synfacts 2009(6): 0581-0581  
DOI: 10.1055/s-0029-1216673
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Cortistatin A

Contributor(s): Philip Kocienski, Arndt W. Schmidt
H. M. Lee, C. Nieto-Oberhuber, M. D. Shair*
Harvard University, Cambridge, USA
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Publikationsverlauf

Publikationsdatum:
25. Mai 2009 (online)

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Significance

Cortistatin A was isolated together with structurally related molecules from the sponge Corticium simplex. It shows potent anti-angiogenetic activity with a high selectivity towards several human and murine cancer cell lines. The focal step of the synthesis is a highly stereoselective aza-Prins cyclization to complete the steroid-like carbon framework (G → H).