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Synthesis of (+)-Psymberin
III, A. B. Smith*, J. A. Jurica, S. P. Walsh
University of Pennsylvania, Philadelphia, USA
25 May 2009 (online)
The synthesis of the sponge cytotoxin (+)-psymberin features a Curtius rearrangement for introducing the N,O-aminal with high diastereoselectivity (J → K). A related process for the synthesis of mycalamide B has been described (P. Kocienski et al. Synlett 1998, 869).