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Synfacts 2009(6): 0655-0655
DOI: 10.1055/s-0029-1216682
DOI: 10.1055/s-0029-1216682
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Nickel-Catalyzed Coupling of Alkyl Halides and Alkyl Grignard Reagents
O. Vechorkin, X. Hu*
Ecole Polytechnique Fédérale de Lausanne, Switzerland
Further Information
Publication History
Publication Date:
25 May 2009 (online)
Significance
Grignard reagents are desirable nucleophiles in coupling
reactions, since they are inexpensive and easy to prepare. The use
of a
pincer nickel complex (1)
enables their highly efficient sp³-sp³ cross-coupling
with alkyl bromides and iodides. The reaction proceeds at low temperatures,
so that even highly reactive functionalities like ketones are tolerated.