Synfacts 2009(6): 0665-0665  
DOI: 10.1055/s-0029-1216683
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Iron-Catalyzed Oxidative Aryl-Alkyl Cross-Coupling of Organozinc Reagents

Contributor(s): Paul Knochel, Andrei Gavryushin
G. Cahiez*, L. Foulgoc, A. Moyeux
Université de Paris 13, Bobigny, France
Further Information

Publication History

Publication Date:
25 May 2009 (online)


This reaction is the first example of aryl-alkyl oxidative cross-coupling. Functionalized aryl and alkyl zinc compounds can be used successfully. The reaction proceeds in the presence of an environmentally benign iron catalyst. This method opens a way to new types of cross-couplings, complementary to the classical variant.