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Rhodium Disulfoxide Catalyzed 1,4-Addition to Cyclic Olefins
J. J. Bürgi, R. Mariz, M. Gatti, E. Drinkel, X. Luan, S. Blumentritt, A. Linden, R. Dorta*
Universität Zürich, Switzerland
25 May 2009 (online)
New disulfoxide ligands are synthesized and successfully applied to the rhodium-catalyzed asymmetric 1,4-addition of aryl boronic acids to cyclic unsaturated ketones or lactones. Very high chemical yields and enantioselectivities are obtained with less than 1 mol% catalyst loading in this reaction. Mechanistic insights of this new ligand and the origin of enantioselectivity are also discussed.