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Synfacts 2009(6): 0689-0689
DOI: 10.1055/s-0029-1216756
DOI: 10.1055/s-0029-1216756
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Mesoporous SBA-15-Supported Catalysts for the Hydrogenation of Ketones
G. Liu*, M. Liu, Y. Sun, J. Wang, C. Sun, H. Li*
Shanghai Normal University, P. R. of China
Further Information
Publication History
Publication Date:
25 May 2009 (online)
Significance
Mesoporous silica-supported chiral rhodium and ruthenium catalysts 4 and 5 were prepared by mixing SBA-15 (pore size of 7.6 nm) and the organometallic complexes RhCl[(R)-MonoPhos(CH2)3Si(OMe)3][(R,R)-DPEN] and RuCl2[(R)-MonoPhos(CH2)3Si(OMe)3][(R,R)-DPEN], which were generated in situ prior to the immobilization (postgrafting protocol). The hydrogenation of ketones 6 was carried out with rhodium catalyst 4 (0.5 mol%) and potassium isopropoxide in i-PrOH under 40 atm H2 to give the corresponding secondary alcohols 7 in 97.6 to >99% conversion (41.7-53.8% ee, 6 examples).