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Brønsted Acid Catalyzed Enantioselective Three-Component Povarov Reaction
H. Liu, G. Dagousset, G. Masson*, P. Retailleau, J. Zhu*
Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France
25 May 2009 (online)
An enantioselective three-component Povarov reaction of aldehydes, anilines, and an enecarbamate is reported. In the presence of chiral phosphoric acid catalyst 1, cis-2,4-disubstituted tetrahydroquinolines 4 are obtained in good yields with excellent enantioselectivity. Both aromatic and aliphatic aldehydes as well as anilines with different electronic properties are suitable substrates.