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Synfacts 2009(6): 0635-0635  
DOI: 10.1055/s-0029-1217148
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Oxidative Cyclization of Enynes Employing a Pd(II)/Pd(IV) Catalytic System

Contributor(s): Mark Lautens, David A. Candito
T. Tsujihara, K. Takenaka, K. Onitsuka, M. Hatanaka, H. Sasai*
Osaka University and Iwate Medicinal University, Yahawe, Japan
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Publication History

Publication Date:
25 May 2009 (online)

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Significance

The authors report an enantioselective variant of the catalytic cyclization of enynes employing a Pd(II)/Pd(IV) catalytic system previously reported by the groups of Tse and Sanford (J. Am. Chem. Soc. 2007, 129, 4906; J. Am. Chem. Soc. 2007, 129, 5836). Little attention has been paid to asymmetric catalysis involving Pd(II)/Pd(IV) catalytic systems. This report represents the first example of asymmetric catalysis involving such a catalytic system.