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Palladium-Catalyzed Cross-Coupling of Secondary Boronic Esters
D. Imao, B. W. Glasspoole, V. S. Laberge, C. M. Crudden*
Queen’s University, Kingston, Canada
25 May 2009 (online)
The cross-coupling of secondary alkyl organoboron reagents with organohalides has been a significant challenge; consequently there are a limited number of reports in the current literature (e.g., H. Doucet Eur. J. Org. Chem. 2008, 2013). The authors report the palladium-catalyzed cross-coupling of secondary boronic esters with aryl halides proceeding with retention of configuration. This report significantly expands the scope of cross-coupling methodologies employing secondary organoboron reagents.