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Rh-Catalyzed Stereoselective Generation of Substituted Enamides
B. Gourdet, H. W. Lam*
University of Edinburgh, UK
25 May 2009 (online)
Enamide synthesis is a challenging problem in organic synthesis, especially for highly substituted ones. The authors provided an efficient method to generate multisubstituted enamides with high regio- and stereoselectivities via rhodium-catalyzed carbozincation of ynamides, which are much easier to synthesize. A mechanism involving alkenylzinc intermediates was proposed and trisubstituted enamides were synthesized based on this postulation.