Synfacts 2009(7): 0699-0699  
DOI: 10.1055/s-0029-1217238
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Bottromycin A2

Contributor(s): Philip Kocienski
H. Shimamura, H. Gouda, K. Nagai, T. Hirose, M. Ichioka, Y. Furuya, Y. Kobayashi, S. Hirono, T. Sunazuka*, S. Õmura*
Kitasato University, Tokyo, Japan
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22. Juni 2009 (online)


Bottromycin is an antibiotic against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). It has a novel mode of action: it inhibits bacterial protein synthesis by blocking the binding of aminoacyl-tRNA to the A site on the 50S ribosome. No cross resistance to existing drugs has been observed.