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Synthesis of Trichodermamide B
X. Wan, M. M. Joullié*
University of Pennsylvania, Philadelphia, USA
22 June 2009 (online)
Both trichodermamides A and B were isolated from the marine-derived fungus Trichoderma virens. Trichodermamide B possesses cytotoxic activity with an IC50 of 0.32 µg/mL against HCT-116 colon carcinoma. The molecule contains a rare oxazine ring system.