Synfacts 2009(7): 0787-0787  
DOI: 10.1055/s-0029-1217255
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Wacker-Type Oxidation of Alkynes into 1,2-Diketones Using Oxygen

Contributor(s): Paul Knochel, Andrei Gavryushin
W. Ren, Y. Xia, S.-J. Ji, Y. Zhang, X. Wan*, J. Zhao
Soochow University, Suzhou and Nanjing University, P. R. of China
Further Information

Publication History

Publication Date:
22 June 2009 (online)


Internal alkynes can be oxidized in a Wacker-type process, using a Pd(II)/Cu(II) catalyst and O2 as an oxidant, into synthetically useful 1,2-diketones. This reaction is highly efficient for a broad range of functionalized substrates including alkynes bearing two alkyl substituents and affords substituted α-diketones in good yields.