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Wacker-Type Oxidation of Alkynes into 1,2-Diketones Using Oxygen
W. Ren, Y. Xia, S.-J. Ji, Y. Zhang, X. Wan*, J. Zhao
Soochow University, Suzhou and Nanjing University, P. R. of China
22 June 2009 (online)
Internal alkynes can be oxidized in a Wacker-type process, using a Pd(II)/Cu(II) catalyst and O2 as an oxidant, into synthetically useful 1,2-diketones. This reaction is highly efficient for a broad range of functionalized substrates including alkynes bearing two alkyl substituents and affords substituted α-diketones in good yields.