Synfacts 2009(7): 0770-0770  
DOI: 10.1055/s-0029-1217284
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Hydrogenation of Quinolines

Contributor(s): Hisashi Yamamoto, Joshua N. Payette
D.-W. Wang, X.-B. Wang, D.-S. Wang, S.-M. Lu, Y.-G. Zhou*, Y.-X. Li*
Dalian Institute of Chemical Physics and Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
22 June 2009 (online)


In the past decade asymmetric ­hydrogenation reactions of various heteroaro-matic compounds including quinoxaline, pyridine, indole, pyrrole, and furan have been achieved. In 2003 the authors reported the use of [Ir(cod)Cl]2MeO-BiPhep/I2 for enantioselective ­hydrogenations of quinoline derivatives (J. Am. Chem. Soc. 2003, 125, 10536). In the current ­report the authors disclose a full account of the generality of this method with a variety of functionalized quinolines.