Subscribe to RSS
Aza-Michael Addition Catalyzed by Camphorsulfonyl Hydrazines
L.-Y Chen, H. He, B.-J. Pei, W.-H. Chan, A. W. M. Lee
Hong Kong Baptist University, P. R. of China
22 June 2009 (online)
Lee and coworker report an enantioselective aza-Michael addition catalyzed by sulfonyl hydrazines 1 and TCA as an additive. The addition products were then reduced to the corresponding alcohol. Using aliphatic aldehydes good to moderate yields and enantioselectivities were achieved, whereas aromatic aldehydes were unreactive under these conditions.