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Synfacts 2009(8): 0877-0877  
DOI: 10.1055/s-0029-1217426
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

AlArEt2(THF) as Arylation Reagents for Aldehydes and Ketones

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
S. Zhou, K.-H. Wu, C.-A. Chen, H.-M. Gau*
National Chung Hsing University, Taichung, Taiwan and Anhui Normal University, P. R. of China
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Publication History

Publication Date:
23 July 2009 (online)

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Significance

The authors have developed the atom-economical, mixed aluminum reagents AlArEt2(THF) for the arylation to both aldehydes and ketones. The resulting secondary and tertiary alcohols were obtained in high yields and enan­tioselectivities. In addition, the aluminum reagents were easily prepared from the reactions of either AlEt2Br(THF) with ArMgBr or AlAr3(THF) with AlEt3(THF).