Cu(I)-Catalyzed Asymmetric Conjugate Alkylation with New
NHC Ligands

T. Uchida; T. Katsuki

doi:10.1055/s-0029-1218081

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Synfacts 2009(11): 1235-1235
DOI: 10.1055/s-0029-1218081

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Cu(I)-Catalyzed Asymmetric Conjugate Alkylation with New NHC Ligands

Contributor(s): Hisashi Yamamoto, Zhi Li
T. Uchida, T. Katsuki*
Kyushu University, Fukuoka, Japan

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Publication History

Publication Date:
22 October 2009 (online)

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Significance

A new class of bidentate N-heterocyclic carbene (NHC) ligands are synthesized in three easy steps. The effects of these ligands in the copper-catalyzed asymmetric conjugate alkylation of acyclic enones with dialkylzinc are examined and high enantioselectivities are obtained.