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Synfacts 2009(11): 1279-1279
DOI: 10.1055/s-0029-1218115
DOI: 10.1055/s-0029-1218115
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles]
X.-H. Chen, Q. Wei, S.-W. Luo, H. Xiao, L.-Z. Gong*
University of Science and Technology of China, Hefei and Chengdu Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
22 October 2009 (online)
Significance
An organocatalytic asymmetric synthesis of spirooxindole derivatives 5 via a three-component 1,3-dipolar cycloaddition of methyleneindolinones 2 with aldehydes 3 and amino esters 4 has been described. Chiral phosphoric acid 1 provided products in high yield with very high regiochemistry (5/6 generally >99:1) and high enantioselectivity.