Benzylic Allylation of 2-Substituted Pyridines

Significance

Asymmetric allylic substitutions have received considerable attention over the previous decade (see Review below). Construction of products with contiguous stereocenters through this strategy, however, is still challenging. Following their report on the use of 2-methylpyridines as nucleophiles in the allylation reaction (J. Am. Chem. Soc. 2008, 130, 14092), the authors describe an extension of their work to more substituted pyridines accessing products with adjacent stereocenters.