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A Versatile Ligand for Suzuki-Miyaura Coupling of Tosylates and Mesylates
B. Bhayana, B. P. Fors, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
20 November 2009 (online)
Recently, aryl tosylates and mesylates have attracted significant attention as cross-coupling partners. Herein, a new highly efficient catalytic system for the Suzuki-Miyaura cross-coupling of these compounds is described. The new ligand BrettPhos allows a high-yielding reaction between aryl sulfonates and a variety of organoborates, including previously unreactive hetero-aryl boronic esters, methyl- and cyclopropylboronic acids.