Synfacts 2009(12): 1385-1385  
DOI: 10.1055/s-0029-1218165
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A Versatile Ligand for Suzuki-Miyaura Coupling of Tosylates and Mesylates

Contributor(s): Paul Knochel, Andrei Gavryushin
B. Bhayana, B. P. Fors, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
Further Information

Publication History

Publication Date:
20 November 2009 (online)


Recently, aryl tosylates and mesylates have attracted significant attention as cross-coupling partners. Herein, a new highly efficient catalytic system for the Suzuki-Miyaura cross-coupling of these compounds is described. The new ligand BrettPhos allows a high-yielding reaction between aryl sulfonates and a variety of organoborates, including previously unreactive hetero-aryl boronic esters, methyl- and cyclopropyl­boronic acids.