Subscribe to RSS
Nickel-Catalyzed Addition of Organo-boronates to Aldehydes and Ketones
J. Bouffard, K. Itami*
Nagoya University, Japan
20 November 2009 (online)
A Ni(0)-NHC catalyst efficiently promotes the 1,2-addition of arylboronate esters to carbonyl compounds. This method allows obtaining a variety of benzylic alcohols, including sterically hindered ones and substituted triarylmethanols. The procedure is relatively simple, employs mild conditions, and tolerates the presence of various functional groups in the reactants.