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Ni-Catalyzed Sonogashira Coupling of Nonactivated Alkyl Halides
O. Vechorkin, D. Barmaz, V. Proust
Ecole Polytechnique Fédérale de Lausanne, Switzerland
20 November 2009 (online)
The Sonogashira cross-coupling of nonactivated, β-H-containing alkyl halides is a highly challenging reaction. Use of nickel(II) pincer complex 1, developed by the authors, allows for a simple and versatile coupling of functionalized alkyl halides, including chlorides, with various terminal alkynes. This is an excellent method for the preparation of internal alkynes.