Synfacts 2009(12): 1374-1374  
DOI: 10.1055/s-0029-1218239
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed Allylic Alkylation and Amination Reactions with Sulfinylphosphines

Contributor(s): Hisashi Yamamoto, Joshua N. Payette
J. Chen, F. Lang, D. Li, L. Cun, J. Zhu, J. Deng, J. Liao*
Chengdu Institute of Organic Chemistry, Graduate School of Chinese Academy of Sciences, Beijing, and Jiangxi Normal University, Nanchang, P. R. of China
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20. November 2009 (online)


Palladium-catalyzed asymmetric allylic alkylation (AAA) reactions are well known and many chiral ligands for this transformation have already been developed. In 1995, Shibasaki and co-workers were the first to demonstrate the applicability of the (S,S)-1,2-bis(4-tolylsulfinyl) benzene ligand in AAA reactions (Tetrahedron Lett. 1995, 36, 8035). Since then, numerous related ligands have appeared in the literature. In the present report, the authors describe a new tert-butanesulfinylphosphine ligand (L1) and its use in AAA and allylic amination reactions.