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Synthesis of Chiral Secondary Amines by Gold(I)-Chiral Brønsted Acid Catalysis
X.-Y. Liu, C.-M. Che*
The University of Hong Kong, P. R. of China
20 November 2009 (online)
Cooperative catalysis has received a surge of interest for developing novel organic transformations with good reactivity and selectivity (see Review below). The authors report a method for the synthesis of enantiomerically enriched secondary amines with excellent ee values through the tandem intermolecular hydroamination-transfer hydrogenation of alkynes using a ”gold(I) complex-chiral Brønsted acid" protocol.
Review: Y. J. Park, J.-W. Park, C.-H. Jun Acc. Chem. Res. 2008, 41, 222-234.