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Synfacts 2009(12): 1363-1363  
DOI: 10.1055/s-0029-1218248
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Chiral Secondary Amines by Gold(I)-Chiral Brønsted Acid Catalysis

Contributor(s): Mark Lautens, Chit Tsui
X.-Y. Liu, C.-M. Che*
The University of Hong Kong, P. R. of China
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Publikationsdatum:
20. November 2009 (online)

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Significance

Cooperative catalysis has received a surge of interest for developing novel organic transformations with good reactivity and selectivity (see Review below). The authors report a method for the synthesis of enantiomerically enriched secondary amines with excellent ee values through the tandem intermolecular hydroamination-transfer hydrogenation of alkynes using a ”gold(I) complex-chiral Brønsted acid" protocol.

Review: Y. J. Park, J.-W. Park, C.-H. Jun Acc. Chem. Res. 2008, 41, 222-234.